Frontiers in Medicine | |
Neutrophils Modulate Fibrogenesis in Chronic Pulmonary Diseases | |
article | |
Lili Ding1  Juan Yang1  Chunmei Zhang2  Xiuna Zhang3  Pujun Gao4  | |
[1] Department of Intensive Care Unit, The First Hospital of Jilin University;Intensive Care Unit of Emergency Department, China-Japan Union Hospital of Jilin University;Department of Hepatology and Gastroenterology, The Second Part of First Hospital, Jilin University;Department of Hepatology, The First Hospital of Jilin University, Jilin University | |
关键词: neutrophils; asthma; chronic obstructive pulmonary disease; cystic fibrosis; idiopathic pulmonary fibrosis; fibrosis; fibrogenesis; | |
DOI : 10.3389/fmed.2021.616200 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Frontiers | |
【 摘 要 】
Chronic inflammatory pulmonary diseases are characterized by recurrent and persistent inflammation of the airways, commonly associated with poor clinical outcomes. Although their etiologies vary tremendously, airway neutrophilia is a common feature of these diseases. Neutrophils, as vital regulators linking innate and adaptive immune systems, are a double-edged sword in the immune response of the lung involving mechanisms such as phagocytosis, degranulation, neutrophil extracellular trap formation, exosome secretion, release of cytokines and chemokines, and autophagy. Although neutrophils serve as strong defenders against extracellular pathogens, neutrophils and their components can trigger various cascades leading to inflammation and fibrogenesis. Here, we review current studies to elucidate the versatile roles of neutrophils in chronic pulmonary inflammatory diseases and describe the common pathogenesis of these diseases. This may provide new insights into therapeutic strategies for chronic lung diseases.
【 授权许可】
CC BY
【 预 览 】
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