High-Dose Ibuprofen in Cystic Fibrosis

Pharmaceuticals

Larry C. Lands¹ 

[1] Division of Respiratory Medicine, Montreal Children’s Hospital, D-380, 2300 Tupper Street, Montreal, Quebec, H3H 1P3, Canada

关键词: ibuprofen;    interleukin-8;    neutrophils;    cystic fibrosis;    CFTR;   

DOI  :  10.3390/ph3072213

来源: mdpi

【 摘 要 】

Cystic Fibrosis (CF) is the most common lethal genetic disorder in North America and Europe. Most patients succumb to progressive lung disease characterized by an exaggerated neutrophilic inflammation. In animal models of chronic infection, high-dose ibuprofen was demonstrated to reduce inflammation without hindering bacterial clearance. This led to two clinical trials, which demonstrated a benefit in slowing the progression of lung disease in CF. However, concerns about potential adverse effects have limited the use of high-dose ibuprofen in CF patients. There are a variety of potential mechanisms to account for the observed clinical benefit. A better understanding of these mechanisms could potentially lead to more targeted and better-tolerated anti-inflammatory therapies.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.