Comparison of neurocognitive changes among newly diagnosed tuberculosis patients with and without dysglycaemia

BMC Psychiatry

Vincent Boima¹  Ida Dzifa Dey¹  Ernest Yorke¹  Vincent Ganu²  Norah Nkornu³  C. Charles Mate-Kole³  Kelvin Samuel Acquaye⁴ 

[1] Department of Medicine & Therapeutics, School of Medicine & Dentistry, College of Health Sciences, University of Ghana;Department of Medicine, Korle-Bu Teaching Hospital;Department of Psychology, School of Social Sciences, College of Humanities, University of Ghana;Department of Social and Behavioural Sciences, School of Public Health, University of Ghana;

关键词: Tuberculosis;    Smear positive;    Dysglycaemia;    Neuropsychological disorders;   

DOI  :  10.1186/s12888-020-02570-8

来源: DOAJ

【 摘 要 】

Abstract Background Diabetes often occurs together with tuberculosis (TB) and both may affect each other negatively. Diabetes may be associated with neurocognitive dysfunctioning in affected patients and may negatively impact treatment adherence and outcomes. This study compared the neurocognitive status between newly diagnosed smear positive tuberculosis patients with dysglycaemia and those with normoglycaemia. Methods The current study was a cross-sectional study involving one hundred and forty-six (146) newly diagnosed smear positive TB patients. Oral glucose tolerance test (OGTT) was performed and the results were categorized as either normoglycaemia, impaired glucose tolerance (IGT), impaired fasting glucose (IFG) or diabetes. Neurocognitive functioning among study participants was assessed at the time of TB diagnosis using Cognitive Failure Questionnaire (CFQ), Montreal Cognitive Assessment tool (MoCA), California Verbal Learning Test (CVLT), Brief Symptom Inventory (BSI) and the Spitzer Quality of Life Index (QLI). Results The mean age of the participants (n = 146) was 38.7 years with 78.8% being males and 21.2% females. Using the fasting blood glucose test, the prevalence of impaired fasting glucose and diabetes were 5.5 and 3.4% respectively, both representing a total of 13 out of the 146 participants; whilst the prevalence of impaired glucose tolerance and diabetes using 2-h post-glucose values were 28.8 and 11.6% respectively, both representing a total of 59 out of the 146 participants. There were no significant differences in the mean scores on the neurocognitive measures between the dysglaycaemia and normoglycamic groups using fasting plasma glucose (FPG). However, there were significant differences in the mean scores between the dysglycaemia and normal groups using 2-h postprandial (2HPP) glucose values on Phobic Anxiety (Normal, Mean = 0.38 ± 0.603; dysglycaemia, Mean = 0.23 ± 0.356; p = 0.045), and Montreal Cognitive Assessment (MoCA) scores (17.26 ± 5.981 vs. 15.04 ± 5.834, p = 0.037). Conclusion Newly diagnosed smear positive patients with dysglycaemia were associated with significantly lower mean cognitive scores and scores on phobic anxiety than those with normoglyacaemia. The latter finding must be further explored.

【 授权许可】

Unknown