Serum lipids profiling perturbances in patients with ischemic heart disease and ischemic cardiomyopathy

Lipids in Health and Disease

Bowen Lou¹  Zuyi Yuan¹  Yue Wu¹  Jianqing She¹  Yangyang Deng¹  Lizhe Sun¹  Liang Wang²  Junhui Liu³  Bo Zhou⁴  Lin Yang⁵ 

[1] Cardiovascular Department, First Affiliated Hospital of Medical College, Xi’an Jiaotong University;Department of cardiovascular surgery, The general hospital of Ningxia Medical Univetsity;Diagnostic Department, First Affiliated Hospital of Medical College, Xi’an Jiaotong University;Respiratory Department, First Affiliated Hospital of Medical College, Xi’an Jiaotong University;Vascular surgery Department, First Affiliated Hospital of Xi’an Jiaotong University;

关键词: Cardiovascular disorders;    Ischemic heart disease;    Ischemic cardiomyopathy;    Lipidomics;    Biomarkers;   

DOI  :  10.1186/s12944-020-01269-9

来源: DOAJ

【 摘 要 】

Abstract Background Ischemic heart disease (IHD) is a common cardiovascular disorder associated with inadequate blood supply to the myocardium. Chronic coronary ischemia leads to ischemic cardiomyopathy (ICM). Despite their rising prevalence and morbidity, few studies have discussed the lipids alterations in these patients. Methods In this cross-sectional study, we analyzed serum lipids profile in IHD and ICM patients using a lipidomics approach. Consecutive consenting patients admitted to the hospital for IHD and ICM were enrolled. Serum samples were obtained after overnight fasting. Non-targeted metabolomics was applied to demonstrate lipids metabolic profile in control, IHD and ICM patients. Results A total of 63 and 62 lipids were detected in negative and positive ion mode respectively. Among them, 16:0 Lyso PI, 18:1 Lyso PI in negative ion mode, and 19:0 Lyso PC, 12:0 SM d18:1/12:0, 15:0 Lyso PC, 17:0 PC, 18:1–18:0 PC in positive ion mode were significantly altered both in IHD and ICM as compared to control. 13:0 Lyso PI, 18:0 Lyso PI, 16:0 PE, 14:0 PC DMPC, 16:0 ceramide, 18:0 ceramide in negative ion mode, and 17:0 PE, 19:0 PC, 14:0 Lyso PC, 20:0 Lyso PC, 18:0 PC DSPC, 18:0–22:6 PC in positive ion mode were significantly altered only in ICM as compared to IHD and control. Conclusion Using non-targeted lipidomics profiling, we have successfully identified a group of circulating lipids that were significantly altered in IHD and ICM. The lipids metabolic signatures shed light on potential new biomarkers and therapeutics for preventing and treating ICM.

【 授权许可】

Unknown