Comparison of ventricular tachyarrhythmia recurrence between ischemic cardiomyopathy and dilated cardiomyopathy: a retrospective study

PeerJ

article

Chih-Yuan Fang¹  Huang-Chung Chen¹  Yung-Lung Chen¹  Tzu-Hsien Tsai¹  Kuo-Li Pan²  Yu-Sheng Lin²  Mien-Cheng Chen¹  Wei-Chieh Lee¹ 

[1] Cardiology, Kaohsiung Chang Gung Memorial Hospital;Chang Gung University College of Medicine;Cardiology, Chang Gung Memorial Hospital

关键词: Implantable cardioverter-defibrillator;    Ventricular tachyarrhythmia;    Ischemic cardiomyopathy;    Dilated cardiomyopathy;   

DOI  :  10.7717/peerj.5312

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background The use of an implantable cardioverter-defibrillator (ICD) has been established as an effective secondary prevention strategy for ventricular tachycardia (VT)/ventricular fibrillation (VF). However, few reports discuss the difference in clinical predictors for recurrent VT/VF between patients with ischemic cardiomyopathy (ICM) and patients with dilated cardiomyopathy (DCM). Methods From May 2004 to December 2015, 132 consecutive patients who had ICM (n = 94) or DCM (n = 38) and had received ICD implantation for secondary prevention were enrolled in this study. All anti-tachycardia events during follow-up were validated. The clinical characteristics and echocardiographic parameters were obtained for comparison. The incidence of recurrence of VT/VF, cardiovascular mortality, all-cause mortality, the change of left ventricular ejection fraction (LVEF) and LV volume were analyzed. Results At a mean follow-up of 3.62 ± 2.93 years, 34 patients (36.2%) in the ICM group and 22 patients (57.9%) in the DCM group had a recurrence of VT/VF episodes (p = 0.032). The DCM group had a lower LVEF (p = 0.019), a larger LV end-diastolic volume (LVEDV) (p158 mL (p = 0.010), and a larger LV end-systolic volume (p158 mL and no use of angiotensin-converting-enzyme inhibitor/angiotensin receptor blocker were independent predictors of recurrences of VT/VF in ICM patients but not in DCM patients. There were no difference in cardiovascular mortality and all-cause mortality between the ICM and DCM patients. Conclusion The DCM patients had a higher recurrence rate of VT/VF than did the ICM patients during long-term follow-up. An enlarged LV is an independent predictor of the recurrence of VT/VF in ICM patients receiving ICD for secondary prevention.

【 授权许可】

CC BY