Neck circumference in relation to glycemic parameters: a systematic review and meta-analysis of observational studies

Diabetology & Metabolic Syndrome

Mohammad Hossein Rouhani¹  Abed Ghavami¹  Parvane Saneei¹  Farnaz Shahdadian¹  Sajjad Moradi²  Hamed Mohammadi³ 

[1] Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences;Halal Research Center of IRI, FDA;Students’ Research Committee, Isfahan University of Medical Sciences;

关键词: Neck circumference;    Fasting plasma glucose;    Insulin levels;    Insulin resistance;    Glycated hemoglobin;   

DOI  :  10.1186/s13098-019-0445-7

来源: DOAJ

【 摘 要 】

Abstract Background Recent studies have suggested that neck circumference (NC) is a supplemental screening measure for diagnosing metabolic complications and might be associated with glycemic parameters. The aim of the present study was to to evaluate the association between NC and glycemic parameters. Methods We systematically searched the electronic databases (including MEDLINE, Scopus, EMBASE, and Google scholar) up to April 2018. Observational studies that reported correlation coefficient between NC and glycemic parameters were included in the analysis. A random effects model was used to estimate overall Fisher’s Z and 95% confidence interval of glycemic parameters including fasting plasma glucose (FBG), serum fasting insulin level, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and glycated hemoglobin (HbA1c). Results A total of 21 studies (44,031 participants) were eligible for including in the systematic review and meta-analysis. Significant correlations were found between NC and FBG (Fisher’s Z = 0.18; 95% CI 0.16, 0.21), serum fasting insulin level (Fisher’s Z = 0.34; 95% CI 0.26, 0.41), HOMA-IR (Fisher’s Z = 0.36; 95% CI 0.29, 0.43) and HbA1c (Fisher’s Z = 0.14; 95% CI 0.09, 0.20). Meta-regression analysis showed that NC were marginally associated with FBG in a linear manner (β = 0.008, P = 0.09); but not related to serum fasting insulin level, HOMA-IR, and HbA1c. Conclusions This meta-analysis of cross-sectional studies showed that NC was positively correlated with glycemic parameters including FBG, serum fasting insulin level, HOMA-IR, and HbA1c. Further investigations with prospective design are required to confirm these findings.

【 授权许可】

Unknown