Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: the Cardiometabolic Risk in Chinese (CRC) study

Diabetology & Metabolic Syndrome

Lu Qi¹  Zilin Sun²  Lianjun Dou³  Yu Wang³  Caiyan Zou³  Xuekui Liu³  Fei Teng³  Jun Liang³ 

[1] Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA;Institute of diabetes, Medical School, Southeast University, Nanjing 210009, Jiangsu, China;Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College; Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou 221009, Jiangsu, China

关键词: Synergistic effects;    Triglyceride;    Uric acid;    Neck circumference;    Insulin resistance;   

Others  :  1114916
DOI  :  10.1186/1758-5996-6-116

 received in 2014-08-17, accepted in 2014-10-23,  发布年份 2014

【 摘 要 】

Objectives

Recent studies have associated neck circumference (NC) with insulin resistance (IR). We examined whether such relation was modified by other metabolic risk factors.

Methods

The study samples were from a community-based health examination survey in central China. A total of 2588 apparently healthy Chinese men and women were included.

Results

Plasma levels of total cholesterol (TC), HDL-C, uric acid (UA) and diastolic blood pressure (DBP) were independently associated with NC after adjusted for age, sex, body mass index (BMI), waist circumference (WC) and hip circumference (HC) (P = 0.009, 0.001, 0.015 and 0.015, respectively). We observed significant interactions of NC with triglyceride (TG) and UA (all the p for interaction = 0.001) in relation to HOMA-IR. It appeared that the associations between NC and HOMA-IR were more evident in those with higher UA or TG level.

Conclusions

Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance.

【 授权许可】

   
2014 Liang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Preis SR, Massaro JM, Hoffmann U, D’Agostino RB Sr, Levy D, Robins SJ, Meigs JB, Vasan RS, O’Donnell CJ, Fox CS: Neck circumference as a novel measure of cardiometabolic risk: the Framingham Heart study. J Clin Endocrinol Metab 2010, 95:3701-3710.
• [2]Liang J, Teng F, Li Y, Liu X, Zou C, Wang Y, Li H, Qi L: Neck circumference and insulin resistance in Chinese adults: the Cardiometabolic Risk in Chinese (CRC) study. Diabetes Care 2013, 36(9):e145-e146.
• [3]Onat A, Hergenç G, Yüksel H, Can G, Ayhan E, Kaya Z, Dursunoğlu D: Neck circumference as a measure of central obesity: associations with metabolic syndrome and obstructive sleep apnea syndrome beyond waist circumference. Clin Nutr 2009, 28:46-51.
• [4]Kurtoglu S, Hatipoglu N, Mazicioglu MM, Kondolot M: Neck circumference as a novel parameter to determine metabolic risk factors in obese children. Eur J Clin Invest 2012, 42:623-630.
• [5]Ahbab S, Ataoğlu HE, Tuna M, Karasulu L, Cetin F, Temiz LU, Yenigün M: Neck circumference. metabolic syndrome and obstructive sleep apnea syndrome; evaluation of possible linkage. Med Sci Monit 2013, 13:111-117.
• [6]Liang J, Zhou N, Teng F, Zou C, Xue Y, Yang M, Song H, Qi L: Hemoglobin A1c levels and aortic arterial stiffness: the Cardiometabolic Risk in Chinese (CRC) study. PLoS One 2012, 7:e38485.
• [7]Liang J, Li Y, Zhou N, Teng F, Zhao J, Zou C, Qi L: Synergistic effects of serum uric Acid and cardiometabolic risk factors on early stage atherosclerosis: the cardiometabolic risk in chinese study. PLoS One 2012, 7:e51101.
• [8]Liang J, Xue Y, Zou C, Zhang T, Song H, Qi L: Serum uric acid and prehypertension among Chinese adults. J Hypertens 2009, 27:1761-1765.
• [9]Teng F, Zhu R, Zou C, Xue Y, Yang M, Song H, Liang J: Interaction between serum uric acid and triglycerides in relation to blood pressure. J Hum Hypertens 2011, 25:686-691.
• [10]Wallace TM, Matthews DR: The assessment of insulin resistance in man. Diabet Med 2002, 19:527-534.
• [11]Balkau B, Charles MA: Comment on the provisional report from the WHO consultation. Europe an Group for the Study of Insulin Resistance (EGIR). Diabet Med 1999, 16:442-443.
• [12]Rosenquist KJ, Massaro JM, Pencina KM, D’Agostino RB, Beiser A, O’Connor GT, O’Donnell CJ, Wolf PA, Polak JF, Seshadri S, Fox CS: Neck circumference, carotid wall intima-media thickness, and incident stroke. Diabetes Care 2013, 36(9):e153-e154.
• [13]Fitch KV, Stanley TL, Looby SE, Rope AM, Grinspoon SK: Relationship between neck circumference and cardio metabolic parameters in HIV-infected and non- HIV-infected adults. Diabetes Care 2011, 34:1026-1031.
• [14]Steiropoulos P, Papanas N, Bouros D, Maltezos E: Obstructive sleep apnea aggravates glycemic control across the continuum of glucose homeostasis. Am J Respir Crit Care Med 2010, 182:286.
• [15]Li C, Hsieh MC, Chang SJ: Metabolic syndrome, diabetes, and hyperuricemia. Curr Opin Rheumatol 2013, 25(2):210-216.
• [16]Yue JR, Huang CQ, Dong BR: Association of serum uric acid with body mass index among long-lived Chinese. Exp Gerontol 2012, 47(8):595-600.
• [17]Zhu Y, Hu Y, Huang T, Zhang Y, Li Z, Luo C, Luo Y, Yuan H, Hisatome I, Yamamoto T, Cheng J: High uric acid directly inhibits insulin signalling and induces insulin resistance. Biochem Biophys Res Commun 2014, 447(4):707-714.
• [18]Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Näslund E, Britton T, Concha H, Hassan M, Rydén M, Frisén J, Arner P: Dynamics of fat cell turnover in humans. Nature 2008, 453(7196):783-787.
• [19]Ruiz García R, Sánchez Armengol Á, Luque Crespo E: Blood uric acid levels in patients with sleep-disordered breathing. Arch Bronconeumol 2006, 42(10):492-500.
• [20]Stabe C, Vasques AC, Lima MM, Tambascia MA, Pareja JC, Yamanaka A, Geloneze B: Neck circumference as a simple tool for identifying the metabolic syndrome and insulin resistance: results from the Brazilian Metabolic Syndrome Study. Clin Endocrinol (Oxf) 2013, 78(6):874-881.
• [21]Vallianou NG, Evangelopoulos AA, Bountziouka V, Vogiatzakis ED, Bonou MS, Barbetseas J, Avgerinos PC, Panagiotakos DB: Neck circumference is correlated with triglycerides and inversely related with HDL cholesterol beyond BMI and waist circumference. Diabetes Metab Res Rev 2013, 29(1):90-97.