The Impact of Mother’s Living Environment Exposure on Genome Damage, Immunological Status, and Sex Hormone Levels in Newborns

International Journal of Environmental Research and Public Health

Aleksandra Fucic¹  Nada Sindicic Dessardo²  Nino Sincic²  Vedrana Guszak²  Sasa Kralik²  Jure Krasic²  Mirta Starcevic²  Drago Batinic²  Damir Loncarevic³ 

[1] Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia;Scientific Center of Excellence for Reproductive and Regenerative Medicine (CERRM),10000 Zagreb, Croatia;University Hospital Center Zagreb, 10000, Zagreb, Croatia;

关键词: estradiol;    testosterone;    endocrine disruptor;    newborn;    genome damage;    diet;   

DOI  :  10.3390/ijerph17103402

来源: DOAJ

【 摘 要 】

Background: The aim of this study was to compare for the first time IL-6 (Interleukin 6), testosterone (T) and estradiol (E) levels, their ratio (E/T), micronucleus (MN), and nuclear bridge (NB) frequency between newborns with regard to their mother’s residency and diet. Our results should enable an assessment of the possible environmental endocrine effects and interaction between biomarkers, pointing to possible associated health risks. Methods: Fifty full-term newborns of both sexes, whose mothers were healthy and not occupationally exposed to any known carcinogen, were analyzed. All of the mothers filled in a detailed questionnaire. Results: The results showed significantly higher levels of E in newborns of mothers with agricultural residency than those born by mothers with urban residency. Significantly, lower levels of E were measured in newborns of mothers who drank milk and carbonated beverages more frequently. Testosterone was significantly higher in boys of mothers with agricultural residency than from mothers with urban residency. Residence and other parameters had no impact on the difference in MN frequency. IL-6 levels were higher in newborns of mothers with agricultural residency. NB levels were significantly associated with E. A significant association between E levels and IL-6 was found. Conclusion: Our results were the first to show a significant impact of the mother’s agricultural residency and diet on their newborns’ sex hormone and IL-6 levels and their association.

【 授权许可】

Unknown