Serum BAFF strongly correlates with PsA activity in male patients only – is there a role for sex hormones?

Clinical and Experimental Rheumatology

Georg Pongratz¹  Peter Härle¹  Jürgen Schölmerich¹  Rainer H. Straub¹  Martin Fleck¹ 

关键词: psoriatic arthritis;    psoriasis;    BAFF/BlyS;    testosterone;    estradiol;    gender difference;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: To determine the relationship between serum levels of B cell activating factor belonging to the TNF family (BAFF) and disease activity (DAS28) in psoriatic arthritis (PsA) patients. METHODS: Twenty-two male and 31 female psoriasis patients fulfilling the CASPAR criteria for PsA were recruited for the study. Disease activity was recorded using the disease activity score for 28 joints (DAS28). Whole blood and serum samples were analysed for serum BAFF, estradiol, and testosterone levels. RESULTS: Serum BAFF levels were positively correlated with DAS28 only in male PsA patients (r=0.669, p

【 授权许可】

Unknown