The role of MiRNA-21 in gliomas: Hope for a novel therapeutic intervention?

Toxicology Reports

Ioannis Liampas¹  Leda Kovatsi²  Athina-Maria Aloizou³  George Lazopoulos³  Georgia Pateraki³  Vasileios Siokas³  Alexios-Fotios A. Mentis³  Dimitrios P. Bogdanos⁴  Efthimios Dardiotis⁵  Konstantinos Paterakis⁶  Panayiotis D. Mitsias⁷ 

[1] Public Health Laboratories, Hellenic Pasteur Institute, Athens, Greece;Department of Cardiothoracic Surgery, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Greece;Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece;Department of Neurology, School of Medicine, University of Crete, 71003 Heraklion, Greece;Department of Neurosurgery, University of Thessaly, University Hospital of Larissa, Larissa, Greece;Department of Rheumatology and Clinical Immunology, University General Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, Viopolis 40500, Larissa, Greece;Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece;

关键词: Glioma;    Glioblastoma multiforme;    miRNA-21;    microRNA;    oncomiR;   

DOI  :  

来源: DOAJ

【 摘 要 】

Gliomas are the most common primary brain tumors in adults. They are generally very resistant to treatment and are therefore associated with negative outcomes. MicroRNAs (miRNAs) are small, non-coding RNA molecules that affect many cellular processes by regulating gene expression and, post-transcriptionally, the translation of mRNAs. MiRNA-21 has been consistently shown to be upregulated in glioma and research has shown that it is involved in a wide variety of biological pathways, promoting tumor cell survival and invasiveness. Furthermore, it has been implicated in resistance to treatment, both against chemotherapy and radiotherapy. In this review, we gathered the existent data on miRNA-21 and gliomas, in terms of its expression levels, association with grade and prognosis, the pathways it involves and its targets in glioma, and finally how it leads to treatment resistance. Furthermore, we discuss how this knowledge could be applied in clinical practice in the years to come. To our knowledge, this is the first review to assess in extent and depth the role of miRNA-21 in gliomas.

【 授权许可】

Unknown