“False negative” CSF cryptococcal antigen with clinical meningitis: Case reports and review of literature

Medical Mycology Case Reports

Tadeo K. Kiiza¹  Joshua Rhein²  Morris K. Rutakingirwa² 

[1] Corresponding author. Infectious Diseases Institute, P.O. Box 22418, Kampala, Uganda.;Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda;

关键词: Cryptococcal meningitis;    Lateral flow assay;    Prozone effect;    HIV;    Cryptococcosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

There is an increasing recognition of patients presenting with cryptococcal meningitis despite having a negative CSF cryptococcal antigen (CrAg). In this report, we describe three cases of patients with advanced immunosuppression who presented to hospital with “false negative” CSF cryptococcal antigen, two of whom had a positive fungal culture. We describe the challenge of CSF-CrAg negative cryptococcal meningitis and explore ways to overcome this challenge using newer diagnostic techniques.

【 授权许可】

Unknown