The Role of Vitamins in Neurodegenerative Disease: An Update

Biomedicines

Sachchida Nand Rai¹  Mohan Prasad Singh¹  Harry W.M. Steinbusch²  Payal Singh³  Emanuel Vamanu⁴  Ghulam Ashraf⁵ 

[1]Centre of Biotechnology, University of Allahabad, Prayagraj 211002, India

[2]Department of Cellular Neuroscience, Faculty of Health, Medicine & Life Sciences, Maastricht University, 6211 LK Maastricht, The Netherlands

[3]Department of Zoology, MMV, Banaras Hindu University, Varanasi 221005, India

[4]Faculty of Biotechnology, The University of Agronomic Science and Veterinary Medicine, 59 Marasti blvd, 1 District, 011464 Bucharest, Romania

[5]Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia

关键词: vitamins;    neurodegenerative disease;    Parkinson’s disease;    Alzheimer’s disease;    Huntington disease;    Prion disease;   

DOI  :  10.3390/biomedicines9101284

来源: DOAJ

【 摘 要 】

Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson’s disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.

【 授权许可】

Unknown