Exploring the potential of mindfulness-based therapy in the prevention and treatment of neurodegenerative diseases based on molecular mechanism studies

Frontiers in Neuroscience

Neuroscience

Congcong Wu¹  Yue Feng² 

[1] College of Acupuncture, Moxibustion, and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China;null;

关键词: mindfulness therapy;    neurodegenerative disease;    Parkinson’s disease;    Alzheimer’s disease;    amyotrophic lateral sclerosis;    molecular mechanism;   

DOI  :  10.3389/fnins.2023.1097067

 received in 2022-11-13, accepted in 2023-05-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Neurodegenerative diseases (ND) have received increasing attention due to their irreversibility, but there is still no means to completely cure ND in clinical practice. Mindfulness therapy (MT), including Qigong, Tai Chi, meditation, and yoga, etc., has become an effective complementary treatment modality in solving clinical and subclinical problems due to its advantages of low side effects, less pain, and easy acceptance by patients. MT is primarily used to treat mental and emotional disorders. In recent years, evidence has shown that MT has a certain therapeutic effect on ND with a potential molecular basis. In this review, we summarize the pathogenesis and risk factors of Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), relating to telomerase activity, epigenetics, stress, and the pro-inflammatory transcription factor nuclear factor kappa B (NF-κB) mediated inflammatory response, and analyze the molecular mechanism basis of MT to prevent and treat ND, to provide possible explanations for the potential of MT treatments for ND.

【 授权许可】

Unknown   
Copyright © 2023 Wu and Feng.