Phenolic characterization, antioxidant activities, and inhibitory effects of Physalis angulata and Newbouldia laevis on enzymes linked to erectile dysfunction

International Journal of Food Properties

Seun A. Akomolafe¹  Sunday I. Oyeleye²  Ganiyu Oboh³  Tosin A. Olasehinde⁴ 

[1] Ekiti State University;Federal University of Technology Akure;Federal University of Technology;University of Fort Hare;

关键词: Erectile dysfunction;    phosphodiesterase-5′;    arginase;    antioxidants;    phenolic compounds;    enzyme inhibition;   

DOI  :  10.1080/10942912.2018.1446149

来源: DOAJ

【 摘 要 】

This study reports the phenolic composition, antioxidant activity, and capacity of Physalis angulata and Newbouldia laevis leaves to inhibit enzymes (phosphodiesterase-5′ [PDE-5′], arginase, acetylcholinesterase [AChE], and angiotensin-I converting enzyme [ACE]) linked to erectile dysfunction. High-performance liquid chromatography–diode array detector analysis of the aqueous extracts revealed the presence of phenolic acids (caffeic, ellagic, chlorogenic, and gallic acids) and flavonoids (quercetin, rutin, isoquercitrin, kaempferol, and quercitrin). N. laevis exhibited significantly higher inhibitory effects on PDE-5′, arginase, and ACE activities compared to P. angulata. There was no significant (P < 0.05) difference in the AChE inhibitory activities of both extracts. Furthermore, P. angulata exhibited lower radical scavenging and chelating abilities compared to N. laevis. These findings revealed that P. angulata and N. laevis leaves are good candidates for the development of functional foods with potentials to improve erectile function.

【 授权许可】

Unknown