Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet

Frontiers in Nutrition

Qiuyan Ban¹  Yuze Hu²  Yu Tan²  Chung S. Yang³  Zhiping Wang⁶  Wenshen Zhong⁶  Lian Yang⁶  Guangshan Zhao⁷  Zhe Ren⁷  Yifei Wang⁷ 

[1] College of Horticulture, Henan Agricultural University, Zhengzhou, China;Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China;Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States;Guangdong Province Key Laboratory of Bioengineering Medicine, Guangzhou, China;Guangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, China;Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China;Guangzhou Jinan Biomedicine Research and Development Center Co., Ltd., Guangzhou, China;School of Food Science and Technology, Henan Agricultural University, Zhengzhou, China;

关键词: polydatin;    resveratrol;    non-alcoholic fatty liver disease;    5′-aMP-activated protein kinase;    gut microbiota;    short-chain fatty acids;   

DOI  :  10.3389/fnut.2022.857879

来源: DOAJ

【 摘 要 】

Resveratrol (RES) is considered to be an activator of AMP-activated protein kinase (AMPK) with many reported health benefits. Polydatin (POD) is a natural precursor and glycosylated form of RES. The glycoside structure of POD alters the bioactivity. Overnutrition-stimulated reactive oxygen species (ROS) promote the AMPK suppression and metabolic dysregulation. The present work compared the effects of POD and RES in ameliorating energy homeostasis imbalance in mice fed a high-fructose diet and elucidated the underlying mechanisms of action. Our results showed that POD elevated the fecal levels of valeric acid and caproic acid via modification of gut microbiota, while RES did not significantly influence the levels of fecal short-chain fatty acids (SCFAs). Both POD and RES markedly decreased the oxidative stress and activated the AMPK signaling pathways in the liver. POD and RES exerted a similar effect in alleviating glucose dysmetabolism, but POD was more effective in ameliorating lipid dysmetabolism than RES. Furthermore, valeric acid and caproic acid alone can activate the AMPK and ameliorate hypercholesterolemia, and enhance the effects of POD on improving lipid metabolism in mice. Overall, for the first time, we demonstrated that POD administration elevated the fecal levels of valeric acid and caproic acid by modifying gut microbiota, thus promoting AMPK activation may be the underlying mechanism that POD is superior to RES in alleviating the lipid dysmetabolism. Our results suggest that POD may be an alternative for RES as an AMPK activator.

【 授权许可】

Unknown