Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome

Molecules

Enrique Almanza-Aguilera¹  VicenteMartín Sánchez²  Carmen Sayón-Orea³  Dora Romaguera³  Montserrat Fitó³  Jadwiga Konieczna³  Xavier Pintó³  FranciscoJ. Tinahones³  JosepA. Tur³  Andrés Díaz-López³  Jordi Salas-Salvadó³  MiguelA. Martínez-González³  Miguel Ruiz-Canela³  Ramon Estruch³  RosaMaría Lamuela-Raventós³  Estefanía Toledo³  Vanessa Bullón-Vela⁴  JoséAlfredo Martínez⁴  Itziar Abete⁴  MariaAngeles Zulet⁴  Ana Rodriguez-Mateos⁵  Yifan Xu⁵  Lidia Daimiel⁶ 

[1] Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Research Institute (IMIM), 08007 Barcelona, Spain;Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain;Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain;Department of Nutrition, Food Science and Physiology, Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain;Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King’s College London, SE1 9NH London, UK;Precision Nutrition Program, IMDEA Food, CEI UAM + CSIC, 28049 Madrid, Spain;

关键词: antioxidant;    inflammation;    liver enzymes;    metabolic syndrome;    non-alcoholic fatty liver disease;    resveratrol;   

DOI  :  10.3390/molecules25184340

来源: DOAJ

【 摘 要 】

Metabolic syndrome (MetS) components are strongly associated with increased risk of non-alcoholic fatty liver disease (NAFLD) development. Several studies have supported that resveratrol is associated with anti-inflammatory and antioxidant effects on health status. The main objective of this study was to assess the putative associations between some urinary resveratrol phase II metabolites, cardiometabolic, and liver markers in individuals diagnosed with MetS. In this cross-sectional study, 266 participants from PREDIMED Plus study (PREvención con DIeta MEDiterránea) were divided into tertiles of total urinary resveratrol phase II metabolites (sum of five resveratrol conjugation metabolites). Urinary resveratrol metabolites were analyzed by ultra- performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS), followed by micro-solid phase extraction (µ-SPE) method. Liver function markers were assessed using serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT). Moreover, lipid profile was measured by triglycerides, very-low-density lipoprotein cholesterol (VLDL-c), and total cholesterol/high-density lipoprotein ratio (total cholesterol/HDL). Linear regression adjusted models showed that participants with higher total urine resveratrol concentrations exhibited improved lipid and liver markers compared to the lowest tertile. For lipid determinations: log triglycerides (β_T3 = −0.15, 95% CI; −0.28, −0.02, p-trend = 0.030), VLDL-c, (β_T3 = −4.21, 95% CI; −7.97, −0.46, p-trend = 0.039), total cholesterol/HDL ratio Moreover, (β_T3 = −0.35, 95% CI; −0.66, −0.03, p-trend = 0.241). For liver enzymes: log AST (β_T3 = −0.12, 95% CI; −0.22, −0.02, p-trend = 0.011, and log GGT (β_T3 = −0.24, 95% CI; −0.42, −0.06, p-trend = 0.002). However, there is no difference found on glucose variables between groups. To investigate the risk of elevated serum liver markers, flexible regression models indicated that total urine resveratrol metabolites were associated with a lower risk of higher ALT (169.2 to 1314.3 nmol/g creatinine), AST (599.9 to 893.8 nmol/g creatinine), and GGT levels (169.2 to 893.8 nmol/g creatinine). These results suggested that higher urinary concentrations of some resveratrol metabolites might be associated with better lipid profile and hepatic serum enzymes. Moreover, urinary resveratrol excreted showed a reduced odds ratio for higher liver enzymes, which are linked to NAFLD.

【 授权许可】

Unknown