Objective Olfactory Findings in Hospitalized Severe COVID-19 Patients

Pathogens

CarlosM. Chiesa-Estomba¹  Mohamad Khalife¹  Sven Saussez¹  JeromeR. Lechien¹  Fabrice Journe²  Christophe de Terwangne³  Shahram Machayekhi³  Sammy Place⁴  Morgane Ducarme⁵  Arnaud Marchant⁶  LuigiAngelo Vaira⁷  Giacomo De Riu⁷ 

[1] COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), F92150 Paris, France;Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), B7000 Mons, Belgium;Department of Intensive Care, EpiCURA Hospital, B7000 Hornu, Belgium;Department of Internal Medicine, EpiCURA Hospital, B7000 Baudour, Belgium;Department of Surgery, EpiCURA Hospital, B7000 Hornu, Belgium;Institute for Medical Immunology, Université libre de Bruxelles, B1000 Brussels, Belgium;Maxillofacial Surgery Unit, University Hospital of Sassari, 07100 Sassari, Italy;

关键词: smell;    olfactory;    COVID-19;    coronavirus;    severe;    anosmia;   

DOI  :  10.3390/pathogens9080627

来源: DOAJ

【 摘 要 】

Objective: We investigate the prevalence of the self-reported and objective sudden loss of smell (SLS) in patients with severe coronavirus disease 2019 (COVID-19). Methods: Severe COVID-19 patients with self-reported SLS were recruited at hospitalization discharge. Epidemiological and clinical data were collected. The Sino-nasal Outcome Test-22 (SNOT-22) was used to evaluate rhinological complaints. Subjective olfactory and gustatory functions were assessed with the National Health and Nutrition Examination Survey (NHNES). Objective SLS was evaluated using psychophysical tests. Potential associations between olfactory evaluation and the clinical outcomes (duration of hospitalization; admission biology; one month serology (IgG), and chest computed tomography findings) were studied. Results: Forty-seven patients completed the study (25 females). Subjectively, eighteen (38.3%) individuals self-reported subjective partial or total SLS. Among them, only three and four were anosmic and hyposmic, respectively (38.9%). Considering the objective evaluation in the entire cohort, the prevalence of SLS was 21.3%. Elderly patients and those with diabetes had lower objective olfactory evaluation results than young and non-diabetic individuals. Conclusion: The prevalence of SLS in severe COVID-19 patients appears to be lower than previously estimated in mild-to-moderate COVID-19 forms. Future comparative studies are needed to explore the predictive value of SLS for COVID-19 severity.

【 授权许可】

Unknown