Cumulative Exposure to Ideal Cardiovascular Health and Incident Diabetes in a Chinese Population: The Kailuan Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Xiaohong Zhao¹  Shouling Wu¹  Xin Du¹  Jihong Shi¹  Chunpeng Ji¹  Qiaofeng Song²  Xizhu Wang²  Xiaoxue Liu²  Shuohua Chen³  Liufu Cui⁴  Anxin Wang⁵  Shanshan Li⁶  Yuming Guo⁶  Rachel Huxley⁷ 

[1] Department of Cardiology Kailuan Hospital North China University of Science and Technology Tangshan China;Department of Cardiology Tangshan People's Hospital North China University of Science and Technology Tangshan China;Department of Health Care Center Kailuan Hospital North China University of Science and Technology Tangshan China;Department of Internal Medicine Kailuan Hospital North China University of Science and Technology Tangshan China;Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China;Division of Epidemiology and Biostatistics School of Public Health The University of Queensland Brisbane Queensland Australia;School of Public Health Curtin University Perth Australia;

关键词: cardiovascular disease risk factors;    cumulative exposure;    diabetes mellitus;    epidemiology;    health status;    ideal cardiovascular health;   

DOI  :  10.1161/JAHA.116.004132

来源: DOAJ

【 摘 要 】

Background It is unclear whether ideal cardiovascular health (CVH), and particularly cumulative exposure to ideal CVH (cumCVH), is associated with incident diabetes. We aimed to fill this research gap. Methods and Results The Kailuan Study is a prospective cohort of 101 510 adults aged 18 to 98 years recruited in 2006–2007 and who were subsequently followed up at 2‐ (Exam 2), 4‐ (Exam 3), and 6 (Exam 4)‐year intervals after baseline. The main analysis is restricted to those individuals with complete follow‐up at all 4 examinations and who had no history of diabetes until Exam 3. Cumulative exposure to ideal CVH (cumCVH) was calculated as the summed CVH score for each examination multiplied by the time between the 2 examinations (score×year). Logistic regression models were used to assess the association between cumCVH and incident diabetes. In fully adjusted models, compared with the lowest quintile of cumCVH, individuals in the highest quintile had ~68% (95% confidence interval [CI] 60‐75) lower risk for incident diabetes (compared with 61% [95% CI 52‐69] lower risk when using baseline CVH). Every additional year lived with a 1‐unit increase in ideal CVH was associated with a 24% (95% CI 21‐28) reduction in incident diabetes. Conclusions Ideal CVH is associated with a reduced incidence of diabetes, but the association is likely to be underestimated if baseline measures of CVH exposure are used. Measures of cumulative exposure to ideal CVH are more likely to reflect lifetime risk of diabetes and possibly other health outcomes. Clinical Trial Registration URL: https://www.chictr.org. Unique identifier: ChiCTRTNC‐11001489.

【 授权许可】

Unknown