A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

Frontiers in Oncology

Shuangfeng Chen¹  Yuebo Li²  Sisi Deng²  Lili Qian²  Luwen Liu²  Ying Zhou²  Weihua Xiao⁴ 

[1] Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China;Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China;Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China;Institute of Immunology, University of Science and Technology of China, Hefei, China;

关键词: microbiota dysbiosis;    molecular subtypes;    treatment strategy;    prognosis;    molecular characteristic;    endometrioid ovarian cancer;   

DOI  :  10.3389/fonc.2021.668151

来源: DOAJ

【 摘 要 】

Ovarian cancer is one of the most common gynecologic cancers that has the highest mortality rate. Endometrioid ovarian cancer, a distinct subtype of epithelial ovarian cancer, is associated with endometriosis and Lynch syndrome, and is often accompanied by synchronous endometrial carcinoma. In recent years, dysbiosis of the microbiota within the female reproductive tract has been suggested to be involved in the pathogenesis of endometrial cancer and ovarian cancer, with some specific pathogens exhibiting oncogenic having been found to contribute to cancer development. It has been shown that dysregulation of the microenvironment and accumulation of mutations are stimulatory factors in the progression of endometrioid ovarian carcinoma. This would be a potential therapeutic target in the future. Simultaneously, multiple studies have demonstrated the role of four molecular subtypes of endometrioid ovarian cancer, which are of particular importance in the prediction of prognosis. This literature review aims to compile the potential mechanisms of endometrioid ovarian cancer, molecular characteristics, and molecular pathological types that could potentially play a role in the prediction of prognosis, and the novel therapeutic strategies, providing some guidance for the stratified management of ovarian cancer.

【 授权许可】

Unknown