Prognostic Significance of Interferon-γ and Its Signaling Pathway in Early Breast Cancer Depends on the Molecular Subtypes

International Journal of Molecular Sciences

Mathias Gehrmann¹  Anne-Sophie Heimes²  Antje Lebrecht²  Slavomir Krajnak²  Katrin Almstedt²  Walburgis Brenner²  Annette Hasenburg²  Marcus Schmidt²  MarcoJ. Battista²  Franziska Härtner³  JanG. Hengstler⁴  Karolina Edlund⁴  Ugur Sahin⁵ 

[1] Bayer AG, 42113 Wuppertal, Germany;Department of Obstetrics and Gynecology, University Medical Center Mainz, 55131 Mainz, Germany;Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, 55131 Mainz, Germany;Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany;TRON-Translational Oncology at the University Medical Center Mainz, 55131 Mainz, Germany;

关键词: interferon;    breast cancer;    prognosis;    molecular subtypes;   

DOI  :  10.3390/ijms21197178

来源: DOAJ

【 摘 要 】

Interferons are crucial for adaptive immunity and play an important role in the immune landscape of breast cancer. Using microarray-based gene expression analysis, we examined the subtype-specific prognostic significance of interferon-γ (IFN-γ) as a single gene as well as an IFN-γ signature covering the signaling pathway in 461 breast cancer patients. Prognostic significance of IFN-γ, as well as the IFN-γ signature for metastasis-free survival (MFS), were examined using Kaplan–Meier as well as univariate and multivariate Cox regression analyses in the whole cohort and in different molecular subtypes. The independent prognostic significance of IFN-γ as a single gene was limited to basal-like breast cancer (hazard ratio (HR) 2.779, 95% confidence interval (95% CI) 1.117–6.919, p = 0.028). In contrast, the IFN-γ-associated gene signature was an independent prognostic factor in the whole cohort (HR 2.287, 95% CI 1.410–3.633, p < 0.001) as well as in the basal-like (HR 3.458, 95% CI 1.154–10.359, p = 0.027) and luminal B (HR 2.690, 95% CI 1.416–5.112, p = 0.003) molecular subtypes. These results underline the subtype-dependent prognostic influence of the immune system in early breast cancer.

【 授权许可】

Unknown