Prediction of Two Molecular Subtypes of Gastric Cancer Based on Immune Signature

Frontiers in Genetics

Genetics

Ben Liu¹  Kexin Chen¹  Fangfang Song¹  Wei Wang¹  Qiang Zhang²  Dan Wu³  Yichen Yang³  Mengyao Feng³  Yang Li³  Hongru Shen³  Jiani Hu³  Xiangchun Li³  Meng Yang³  Jilei Liu³  Xilin Shen³ 

[1] Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China;Department of Maxillofacial and Otorhinolaryngology Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China;National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China;

关键词: gastric cancer;    immune signature;    molecular subtypes;    prognosis;    computational biology;   

DOI  :  10.3389/fgene.2021.793494

 received in 2021-10-12, accepted in 2021-12-16,  发布年份 2022

来源: Frontiers

【 摘 要 】

Gastric cancer is the fifth most common type of human cancer and the third leading cause of cancer-related death. The purpose of this study is to investigate the immune infiltration signatures of gastric cancer and their relation to prognosis. We identified two distinct subtypes of gastric cancer (C1/C2) characterized by different immune infiltration signatures. C1 is featured by immune resting, epithelial–mesenchymal transition, and angiogenesis pathways, while C2 is featured by enrichment of the MYC target, oxidative phosphorylation, and E2F target pathways. The C2 subtype has a better prognosis than the C1 subtype (HR = 0.61, 95% CI: 0.44–0.85; log-rank test, p = 0.0029). The association of C1/C2 with prognosis remained statistically significant (HR = 0.62, 95% CI: 0.44–0.87; p = 0.006) after controlling for age, gender, and stage. The prognosis prediction of C1/C2 was verified in four independent cohorts (including an internal cohort). In summary, our study is helpful for better understanding of the association between immune infiltration and the prognosis of gastric cancer.

【 授权许可】

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Copyright © 2022 Wu, Feng, Shen, Shen, Hu, Liu, Yang, Li, Yang, Wang, Zhang, Song, Liu, Chen and Li.