Recent Advances on Phagocytic B Cells in Teleost Fish

Frontiers in Immunology

Liting Wu¹  Zhendong Qin²  Jianmin Ye³  Haipeng Liu³  Li Lin³  Jun Li⁴ 

[1] Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Institute of Modern Aquaculture Science and Engineering, School of Life Sciences, South China Normal University, Guangzhou, China;Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Guangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China;Laboratory for Marine Fisheries Science and Food Production Processes, Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, Qingdao, China;School of Science and Medicine, Lake Superior State University, Sault Ste. Marie, MI, United States;State Key Laboratory of Marine Environmental Science, State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Xiamen University, Xiamen, China;

关键词: teleost fish;    B cells;    phagocytosis;    cytokines;    antigen presentation;   

DOI  :  10.3389/fimmu.2020.00824

来源: DOAJ

【 摘 要 】

The momentous discovery of phagocytic activity in teleost B cells has caused a dramatic paradigm shift from the belief that phagocytosis is performed mainly by professional phagocytes derived from common myeloid progenitor cells, such as macrophages/monocytes, neutrophils, and dendritic cells. Recent advances on phagocytic B cells and their microbicidal ability in teleost fish position B cells at the crossroads, bridging innate with adaptive immunity. Most importantly, an increasing body of experimental evidence demonstrates that, in both teleosts and mammals, phagocytic B cells can recognize, take up, and destroy particulate antigens and then present those processed antigens to CD4+ T cells to elicit adaptive immune responses and that the phagocytosis is mediated by pattern recognition receptors and involves multiple cytokines. Thus, current findings collectively indicate that teleost phagocytic B cells, as well as their counterpart mammalian B1-B cells, can be considered one kind of professional phagocyte. The aim of this review is to summarize recent advances regarding teleost phagocytic B cells, with a particular focus on the recognizing receptors and modulating mechanisms of phagocytic B cells and the process of antigen presentation for T-cell activation. We also attempt to provide new insights into the adaptive evolution of the teleost fish phagocytic B cell on the basis of its innate and adaptive roles.

【 授权许可】

Unknown