Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy

Frontiers in Medicine

Tereza Urdih¹  Samo Zver¹  Matjaž Sever¹  Manca Oblak²  Andreja Aleš Rigler²  Urban Švajger³  Primož Poženel³  Katrina Hartman³  Philip P. Halloran⁴  Jadranka Buturović Ponikvar⁵  Gregor Mlinšek⁵  Miha Arnol⁵  Željka Večerić-Haler⁵  Alojz Ihan⁶  Nika Kojc⁷ 

[1] Department of Haematology, University Medical Centre Ljubljana, Ljubljana, Slovenia;Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia;Division for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia;Division of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada;Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia;Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia;Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia;

关键词: mesenchymal stem cell;    kidney graft;    kidney transplant;    kidney graft failure;    autologous stem cell;    stem cell transplant;   

DOI  :  10.3389/fmed.2021.708744

来源: DOAJ

【 摘 要 】

Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.

【 授权许可】

Unknown