Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy

Frontiers in Medicine

article

Željka Večerić-Haler¹  Manca Oblak¹  Andreja Aleš Rigler¹  Alojz Ihan³  Jadranka Buturović Ponikvar¹  Philip P. Halloran⁴  Miha Arnol¹  Nika Kojc⁵  Matjaž Sever²  Samo Zver²  Urban Švajger⁷  Primož Poženel⁷  Katrina Hartman⁷  Tereza Urdih⁶  Gregor Mlinšek¹ 

[1] Department of Nephrology, University Medical Centre Ljubljana;Faculty of Medicine, University of Ljubljana;Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana;Division of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre;Institute of Pathology, Faculty of Medicine, University of Ljubljana;Department of Haematology, University Medical Centre Ljubljana;Division for Cells and Tissue, Blood Transfusion Centre of Slovenia

关键词: mesenchymal stem cell;    kidney graft;    kidney transplant;    kidney graft failure;    autologous stem cell;    stem cell transplant;    kidney graft rejection;    capillary leak syndrome;   

DOI  :  10.3389/fmed.2021.708744

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.

【 授权许可】

CC BY