Orthotopic kidney transplantation survival and complications: systematic review and meta-analysis

Arab Journal of Urology

Antonio Alcaraz¹  Mireia Musquera¹  Carlos Alfredo Castillo-Delgado²  Herney Andrés García-Perdomo³ 

[1] Division of Kidney Transplant Surgery, Department of Urology, Hospital Clinic – University of Barcelona, Barcelona, Spain;Division of Transplant Surgery, Department of General Surgery, Hospital General Plaza de la Salud, Santo Domingo, Dominican Republic;Division of Urology/Urooncology, Department of Surgery, UROGIV Research Group, Universidad del Valle, Cali, Colombia;

关键词: Orthotopic kidney transplantation;    systematic review;    meta-analysis;    kidney graft;    overall survival;   

DOI  :  10.1080/2090598X.2022.2090133

来源: DOAJ

【 摘 要 】

Purpose To determine graft and patient survival and adverse events in patients who undergo orthotopic kidney transplantation.Methods We performed a systematic review and meta-analysis. We search in Medline, Embase, and Central from inception to nowadays. We included observational studies with patients who undergo orthotopic kidney transplantation. The primary outcomes were overall patient and graft survival. We pooled the information in a frequency meta-analysis with a 95% CI. We analyzed bias with the STROBE statement.Results Of the 106 papers initially retrieved, four met the inclusion criteria. Vascular and urinary tract complications were reported in 19% and 15%, respectively. The overall patient survival was 92% 95%CI (88% to 95%), I2 = 0%, and the overall graft survival was 88% 95 CI (83% to 91%), I2 = 0%.Conclusion Our analysis showed a high survival rate in patients and kidney grafts after orthotopic kidney transplantation, with a similar complication rate compared to a heterotopic kidney transplant.

【 授权许可】

Unknown