Electrocorticography reveals beta desynchronization in the basal ganglia-cortical loop during rest tremor in Parkinson's disease

Neurobiology of Disease

Nicole C. Swann¹  Coralie de Hemptinne²  Salman E. Qasim³  Svjetlana Miocinovic⁴  Jill L. Ostrem⁴  Philip A. Starr⁵ 

[1] Broadway, New York, NY 10027, USA.;;Corresponding author at: Columbia University, 116th St &Department of Biomedical Engineering, Columbia University, USA;Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA;Department of Neurology, University of California San Francisco, San Francisco, CA, USA;

关键词: Parkinson's disease;    Electrocorticography (ECoG);    Tremor;    Basal ganglia;    Deep brain stimulation (DBS);   

DOI  :  

来源: DOAJ

【 摘 要 】

The pathophysiology of rest tremor in Parkinson's disease (PD) is not well understood, and its severity does not correlate with the severity of other cardinal signs of PD. We hypothesized that tremor-related oscillatory activity in the basal-ganglia-thalamocortical loop might serve as a compensatory mechanism for the excessive beta band synchronization associated with the parkinsonian state. We recorded electrocorticography (ECoG) from the sensorimotor cortex and local field potentials (LFP) from the subthalamic nucleus (STN) in patients undergoing lead implantation for deep brain stimulation (DBS). We analyzed differences in measures of network synchronization during epochs of spontaneous rest tremor, versus epochs without rest tremor, occurring in the same subjects. The presence of tremor was associated with reduced beta power in the cortex and STN. Cortico-cortical coherence and phase–amplitude coupling (PAC) decreased during rest tremor, as did basal ganglia-cortical coherence in the same frequency band. Cortical broadband gamma power was not increased by tremor onset, in contrast to the movement-related gamma increase typically observed at the onset of voluntary movement. These findings suggest that the cortical representation of rest tremor is distinct from that of voluntary movement, and support a model in which tremor acts to decrease beta band synchronization within the basal ganglia-cortical loop.

【 授权许可】

Unknown