Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds

Molecules

Agata Kabała-Dzik¹  Żaneta Jastrzębska-Stojko²  Jerzy Stojko³  Anna Rzepecka-Stojko⁴  Rafał Stojko⁵ 

[1] Deparment of Pathology School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Ostrogórska 3, 41-200 Sosnowiec, Poland;Department of Anesthesiology and Intensive Care School of Medicine, Medical University of Silesia in Katowice, Medyków 14, 40-752 Katowice, Poland;Department of Hygiene, Bioanalysis and Environmental Studies School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Kasztanowa 3A,41-200 Sosnowiec, Poland;Department of Pharmaceutical Chemistry, School of Pharmacy and Laboratory Medicine,Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland;Department of Women Health, School of Health Sciences, Medical University of Silesia in Katowice, Medyków 12, 40-752 Katowice, Poland;

关键词: propolis;    bee honey;    burn wound;    collagen;    hydroxyproline;   

DOI  :  10.3390/molecules181114397

来源: DOAJ

【 摘 要 】

Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds.These properties are found in apitherapeutics such as propolis and honey—products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of scar formation in experimentally evoked burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of propolis and honey. The results were compared with the therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The level of collagen was determined in the wounds treated with 1% and 3% Sepropol and compared with the collagen level in healthy skin and wounds treated with dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard dermazin therapy.

【 授权许可】

Unknown