Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds

Molecules

ឺneta Jastrzᆛska-Stojko¹  Rafał Stojko²  Anna Rzepecka-Stojko⁴  Agata Kabaᐪ-Dzik³ 

[1] Department of Anesthesiology and Intensive Care School of Medicine, Medical University of Silesia in Katowice, Medyków 14, 40-752 Katowice, Poland; E-Mail:;Department of Women Health, School of Health Sciences, Medical University of Silesia in Katowice, Medyków 12, 40-752 Katowice, Poland;Deparment of Pathology School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Ostrogórska 3, 41-200 Sosnowiec, Poland; E-Mail:;Department of Pharmaceutical Chemistry, School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland; E-Mail:

关键词: propolis;    bee honey;    burn wound;    collagen;    hydroxyproline;   

DOI  :  10.3390/molecules181114397

来源: mdpi

【 摘 要 】

Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey—products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of scar formation in experimentally evoked burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of propolis and honey. The results were compared with the therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The level of collagen was determined in the wounds treated with 1% and 3% Sepropol and compared with the collagen level in healthy skin and wounds treated with dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard dermazin therapy.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.