Recent advances in crystalline and amorphous particulate protein formulations for controlled delivery

Asian Journal of Pharmaceutical Sciences

Lorenz Meinel¹  Sebastian Puhl¹  Oliver Germershaus¹ 

[1] Institute for Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany;

关键词: Protein crystals;    Protein particles;    Protein delivery;    Controlled release;   

DOI  :  10.1016/j.ajps.2016.06.003

来源: DOAJ

【 摘 要 】

The number of particulate delivery systems for biologics is negligible compared to liquid dosage forms, signifying the complications associated with development of solid protein delivery systems. Particulate protein delivery systems can improve stability, reduce viscosity of suspensions at high protein concentration and allow for controlled drug release. This review discusses current advances in controlled delivery of particulate protein formulations. While the focus lies on protein crystals and delivery systems employing protein crystals, amorphous protein particles will also be addressed. Crystallization and precipitations methods and modifications allowing controlled delivery with and without encapsulation are summarized and discussed.

【 授权许可】

Unknown