Differences in breast cancer risk after benign breast disease by type of screening diagnosis

Breast

Laura Comerma¹  Marta Román²  Francina Saladié²  M. Jesús Quintana²  Rodrigo Alcantara³  Margarita Posso³  Javier del Riego³  Xavier Bargalló⁴  Lupe Peñalva⁵  Xavier Castells⁶  María Sala⁷  Javier Louro⁸  Mar Sanchez⁸  Carmen Vidal⁸  Miguel Prieto⁹  Joana Ferrer^1,10 

[1] European Higher Education Area (EHEA) Doctoral Programme in Methodology of Biomedical Research and Public Health in Department of Pediatrics, Obstetrics and Gynecology, Preventive Medicine and Public Health, Universitat Autónoma de Barcelona (UAB), Bellaterra, Barcelona, Spain;Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain;Servei D’Epidemiologia I Avaluació, Hospital Del Mar, Barcelona, Spain;Cancer Epidemiology and Prevention Service, Hospital Universitari Sant Joan de Reus, Institut D’Investigació Sanitària Pere Virgili, Universitat Rovira I Virgili, Reus, Spain;Catalan Institute of Oncology (ICO), Barcelona, Spain;Department of Clinical Epidemiology and Public Health, University Hospital de La Santa Creu I Sant Pau, IIB Sant Pau, Barcelona, Spain;Direction General of Public Health, Cantabria, Spain;IMIM (Hospital Del Mar Medical Research Institute), Barcelona, Spain;Servei de Diagnòstic per La Imatge, Hospital Del Mar, Barcelona, Spain;Servei de Patologia, Hospital Del Mar, Barcelona, Spain;

关键词: Breast neoplasms;    Early cancer detection;    Benign breast disease;    Risk factors;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. Materials and methods: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or proliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer. Results: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value = 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24–3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57–2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09–9.08, and 3.35; 95%CI: 1.51–7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95–2.93, and 1.63; 95%CI: 1.32–2.02 for those diagnosed at incident and prevalent screens, respectively). Conclusion: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis.

【 授权许可】

Unknown