Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold

Nano-Micro Letters

Jinhua Wang¹  Jianfang Wang²  Han Zhang²  Kathy Qian Luo³  Jie Li⁴  Xing-Xing Fan⁴  Xue-Qin Huang⁴  Hong-Ye Wan⁴  Xiao-Ming Zhu⁴  Jian-Li Chen⁴ 

[1] Beijing Key Laboratory of Drug Targets Research and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College;Department of Physics, The Chinese University of Hong Kong;Faculty of Health Sciences, University of Macau;State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology;

关键词: Antiangiogenesis therapy;    Core@shell nanostructures;    Gold nanobipyramids;    Photothermal therapy;    Plasmon resonance;   

DOI  :  10.1007/s40820-019-0327-4

来源: DOAJ

【 摘 要 】

Abstract Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region (1000–1350 nm) are strongly desired for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO2) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO2 nanostructures have a high photothermal conversion efficiency of (93.3 ± 5.2)% under 1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO2 nanostructures combined with PTT induce a synergistic antiangiogenesis effect. In vivo studies show that such CA4P-loaded NBP@TiO2 nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4 W cm−2, which is lower than the skin tolerance threshold value, exhibit a superior antitumor effect. This work presents not only the development of the NBP@TiO2 nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy.

【 授权许可】

Unknown