Crushed Gold Shell Nanoparticles Labeled with Radioactive Iodine as a Theranostic Nanoplatform for Macrophage-Mediated Photothermal Therapy

Nano-Micro Letters

Jae-Eon Lee¹  Jaetae Lee²  Sang Kyoon Kim³  In-Kyu Lee⁴  Sang-Woo Lee⁵  Yong Hyun Jeon⁶  Sang Bong Lee⁷  Jungwook Chin⁷  Sung Jin Cho⁸ 

[1] Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Pusan, South Korea;Department of Nuclear Medicine, Kyungpook National University Hospital, 702-210, Daegu, South Korea;Daegu-Gyeongbuk Medical Innovation Foundation, 360-4, Daegu, South Korea;Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, 360-4, Daegu, South Korea;Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, 702-210, Daegu, South Korea;Department of Internal Medicine, Kyungpook National University School of Medicine, 700-721, Daegu, South Korea;Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, 702-210, Daegu, South Korea;Department of Nuclear Medicine, Kyungpook National University Hospital, 702-210, Daegu, South Korea;Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, 702-210, Daegu, South Korea;Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, 360-4, Daegu, South Korea;New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea;New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea;Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, 702-210, Daegu, South Korea;

关键词: Photothermal therapy;    Radionuclide crushed gold shell nanoballs;    Macrophage-mediated delivery;   

DOI  :  10.1007/s40820-019-0266-0

来源: Springer

【 摘 要 】

tsCrushed gold shell radionuclide nanoballs (124I-Au@AuCBs) were fabricated as unique photothermal therapeutics and nuclear medicine imaging nanoplatforms.Macrophage-mediated delivery of 124I-Au@AuCBs and their potential photothermal therapy applications were demonstrated in mice with colon cancer.

【 授权许可】

CC BY