Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold

Nano-Micro Letters

Jinhua Wang¹  Han Zhang²  Jianfang Wang²  Kathy Qian Luo³  Hong-Ye Wan⁴  Jian-Li Chen⁴  Xue-Qin Huang⁴  Xing-Xing Fan⁴  Xiao-Ming Zhu⁴  Jie Li⁴ 

[1] Beijing Key Laboratory of Drug Targets Research and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, People’s Republic of China;Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People’s Republic of China;Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, People’s Republic of China;State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, People’s Republic of China;

关键词: Antiangiogenesis therapy;    Core@shell nanostructures;    Gold nanobipyramids;    Photothermal therapy;    Plasmon resonance;   

DOI  :  10.1007/s40820-019-0327-4

来源: Springer

【 摘 要 】

tsTitania-coated Au nanobipyramids (NBP@TiO2) with a high photothermal conversion efficiency in the NIR-II window are synthesized.The TiO2 shell is capable for the loading of the anticancer drug combretastatin A-4 phosphate (CA4P).The CA4P-loaded NBP@TiO2 nanostructures subjected with photothermal therapy induce synergistic anticancer and antiangiogenesis effects under 1064-nm laser irradiation at a power density lower than the skin tolerance threshold value.

【 授权许可】

CC BY