Recyclable fluorous cinchona alkaloid ester as a chiral promoter for asymmetric fluorination of β-ketoesters

Beilstein Journal of Organic Chemistry

Wei Zhang¹  Zijuan Zhang¹  Dian-Rong Zhu¹  Xin Huang¹  Chun Cai²  Wen-Bin Yi² 

[1] Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA;School of Chemical Engineering, Nanjing University of Science and Technology, Xiao Ling Wei Street, Nanjing 210094, People’s Republic of China;

关键词: asymmetric fluorination;    β-ketoester;    fluorous cinchona ester;    organocatalysis;    recyclable chiral promoter;   

DOI  :  10.3762/bjoc.8.138

来源: DOAJ

【 摘 要 】

A fluorous cinchona alkaloid ester has been developed as a chiral promoter for the asymmetric fluorination of β-ketoesters. It has comparable reactivity and selectivity to the nonfluorous versions of cinchona alkaloids and can be easily recovered from the reaction mixture by simple fluorous solid-phase extraction (F-SPE) and used for the next round of reaction without further purification.

【 授权许可】

Unknown