Organocatalytic Michael Addition of 1,3-Dicarbonyl Indane Compounds to Nitrostyrenes

Molecules

Zhen-Yu Jiang¹  Hua-Meng Yang¹  Ya-Dong Ju¹  Li Li¹  Meng-Xian Luo¹  Guo-Qiao Lai¹  Jian-Xiong Jiang¹ 

[1] Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310012, China

关键词: organocatalysis;    Michael reaction;    primary amine;    diamine;   

DOI  :  10.3390/molecules15042551

来源: mdpi

【 摘 要 】

To map out the efficient organocatalyst requirements in the Michael addition of 1,3-dicarbonyl indane compounds to nitrostyrenes, a dozen different amino organocatalysts containing a p-toluenesulfonyl group (Ts) have been evaluated; excellent enantio-selectivities (up to er 92:8) were obtained with a primary amine-based Ts-DPEN catalyst and a plausible catalytic reaction mechanism was proposed on the basis of the experimental results.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.