Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals

Neurobiology of Stress

Ana C.V.V. Giacomini¹  Gleb O. Maslov²  Tatyana Strekalova³  Konstantin A. Demin⁴  Elena V. Petersen⁵  Murilo S. de Abreu⁶  Yury Kositsin⁶  Tamara G. Amstislavskaya⁷  Allan V. Kalueff⁸ 

[1] Corresponding author. Bioscience Institute, University of Passo Fundo, Passo Fundo, Brazil.;Granov Russian Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia;Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia;Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia;Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil;Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil;Institute of Experimental Medicine, Almazov National Medcial Research Center, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia;Scientific Research Institute of Physiology and Basic Medcicine, Novosibirsk, Russia;

关键词: Zebrafish;    Rodents;    Cortisol;    Stress axis;    Behavior;    Animal models;   

DOI  :  

来源: DOAJ

【 摘 要 】

Stress response is essential for the organism to quickly restore physiological homeostasis disturbed by various environmental insults. In addition to well-established physiological cascades, stress also evokes various brain and behavioral responses. Aquatic animal models, including the zebrafish (Danio rerio), have been extensively used to probe pathobiological mechanisms of stress and stress-related brain disorders. Here, we critically discuss the use of zebrafish models for studying mechanisms of stress and modeling its disorders experimentally, with a particular cross-taxon focus on the potential evolution of stress responses from zebrafish to rodents and humans, as well as its translational implications.

【 授权许可】

Unknown