Clinical applications of avian eggshell-derived hydroxyapatite

Bosnian Journal of Basic Medical Sciences

Mihaela Baciut¹  Simion Bran¹  Cristian Dinu¹  Horia Opris¹  Daiana Antoaneta Prodan¹  Grigore Baciut¹  Alexandru Mester² 

[1] Department of Maxillofacial Surgery and Implantology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania;Department of Oral Health, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania;

关键词: Bone tissue regeneration;    eggshell;    guided bone regeneration;    hydroxyapatite;    socket preservation;   

DOI  :  10.17305/bjbms.2020.4888

来源: DOAJ

【 摘 要 】

The search for bone reconstruction materials and methods is an ongoing challenge. The aim of this review is to systemically search the available literature concerning the clinical performance of eggshell as a substitute material in guided bone regeneration in oral surgery. Five databases (PubMed, Cochrane, Web of Science, Scopus, and Embase) were searched up to February 2020. Clinical trials that used eggshell as a bone substitute material were included. Animal and in vivo studies were excluded. ROBINS-I was used to evaluate the risk of bias. A total of 840 studies were retrieved, out of which 55 full-text articles were screened. Five studies were finally included: one study showed critical and four serious risk of bias. A total of 74 patients and 88 intervention sites were included in the five studies. Clinical and radiological evaluation showed complete healing during the follow-ups. Statistically significant radiological and clinical evidence of new bone formation was achieved for socket preservation, grafting after third molar extraction, and cystic/apicectomy grafting. One patient with complications was reported. Histological analysis and micro computed tomography confirmed that it promotes bone regeneration. A comparison with synthetic hydroxyapatite showed similar healing characteristics. Within the limitations of the included studies, eggshell can be safely and efficiently used in guided bone regeneration procedures, but more research is needed to completely evaluate the full potential of this material.

【 授权许可】

Unknown