Investigating the physical characteristics and cellular interplay on 3D-printed scaffolds depending on the incorporated silica size for hard tissue regeneration

Materials & Design

Hojun Jeon¹  So-Jung Gwak²  Woonhyeok Jeong³  Hye Hyun Yoo⁴  MyungGu Yeo⁵  Minseong Kim⁵  Bongsu Jung⁵  Min-Jeong Park⁵  Gi Hoon Yang⁶  Eunjeong Choi⁶  Donggu Kang⁶  Yunjoo Nam⁶ 

[1] Corresponding authors.;Department of Chemical Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, South Korea;Department of Plastic and Reconstructive Surgery, Dongsan Medical Center, Keimyung University College of Medicine, 1035 Dalgubeol-daero, Dalseo-gu, Daegu 42601, South Korea;Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, 55 Hanyangdaehak-Ro, Ansan, Gyeonggi-Do 15588, South Korea;Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), 80 Cheombok-ro, Dong-gu, Daegu 41061, South Korea;Research Institute of Additive Manufacturing and Regenerative Medicine, Baobab Healthcare Inc., 55 Hanyangdaehak-Ro, Ansan, Gyeonggi-Do 15588, South Korea;

关键词: Bone tissue regeneration;    Human mesenchymal stem cells;    Polycaprolactone;    Silica particle size;   

DOI  :  

来源: DOAJ

【 摘 要 】

Silica has been widely used in bone tissue regeneration which is known to increase the bone mineral density and reduce bone resorption. In this study, surface modified silica particles with different sizes (100, 500, and 800 nm) were incorporated with polycaprolactone (PCL) to study the influence of silica particle size on physical and biological properties. Controversial results were observed between the physical and biological properties. In terms of physical properties including surface roughness, hydrophilicity, and mechanical strength, the PCL scaffold with 800 nm-sized particles showed significantly enhanced results. However, the scaffold with 100 nm-sized particles significantly upregulated the biological properties such as human mesenchymal stem cell adhesion, proliferation, and differentiation. This was also relevant for the in vivo results. Altogether, the results proved that the silica particle size influence the physical and biological properties of the PCL scaffold.

【 授权许可】

Unknown