Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19

Journal of Clinical Medicine

Ulrike Protzer¹  Sophia E. Schambeck²  Henriette Beyer²  Holger Poppert²  Claudia S. Crowell³  Elvira D’Ippolito³  Dirk H. Busch³  Markus Gerhard³  Karolin I. Wagner³  Teresa Burrell³  Hrvoje Mijočević⁴ 

[1] German Center for Infection Research (DZIF), Partner Site Munich, 81675 Munich, Germany;Helios Klinikum München West, Steinerweg 5, 81241 München, Germany;Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstr. 30, 81675 München, Germany;Institute of Virology, School of Medicine, Technical University of Munich, Trogerstr. 30, 81675 München, Germany;

关键词: parosmia;    phantosmia;    dysgeusia;    smell;    taste;    coronavirus;   

DOI  :  10.3390/jcm10225266

来源: DOAJ

【 摘 要 】

Deficiencies in smell and taste are common symptoms of COVID-19. Quantitative losses are well surveyed. This study focuses on qualitative changes such as phantosmia (hallucination of smell), parosmia (alteration of smell), and dysgeusia (alteration of taste) and possible connections with the adaptive immune system. Subjective experience of deficiency in taste and smell was assessed by two different questionnaires after a median of 100 and 244 days after first positive RT-PCR test. SARS-CoV-2-specific antibody levels were measured with the iFlash-SARS-CoV-2 assay. After 100 days a psychophysical screening test for olfactory and gustatory dysfunction was administered. 30 of 44 (68.2%) participants reported a chemosensory dysfunction (14 quantitative, 6 qualitative, 10 quantitative, and qualitative) during COVID-19, eleven (25.0%) participants (1 quantitative, 7 qualitative, 3 quantitative, and quantity) after 100 days, and 14 (31.8%) participants (1 quantitative, 10 qualitative, 3 quantitative and qualitative) after 244 days. Four (9.1%) participants, who were symptom-free after 100 days reported now recently arisen qualitative changes. Serological and T-cell analysis showed no correlation with impairment of taste and smell. In conclusion, qualitative changes can persist for several months and occur as late-onset symptoms months after full recovery from COVID-19-induced quantitative losses in taste and smell.

【 授权许可】

Unknown