Copper-catalyzed cascade reactions of α,β-unsaturated esters with keto esters

Beilstein Journal of Organic Chemistry

Zhengning Li¹  Chongnian Wang¹  Zengchang Li¹ 

[1] College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China;

关键词: aldol addition;    cascade reaction;    catalysis;    conjugate reduction;    copper;    lactonization;   

DOI  :  10.3762/bjoc.11.23

来源: DOAJ

【 摘 要 】

A copper-catalyzed cascade reaction of α,β-unsaturated esters with keto esters is reported. It features a copper-catalyzed reductive aldolization followed by a lactonization. This method provides a facile approach to prepare γ-carboxymethyl-γ-lactones and δ-carboxymethyl-δ-lactones under mild reaction conditions.

【 授权许可】

Unknown