期刊论文详细信息
Heterocyclic communications | |
A fast and efficient ‘on-solvent’ cascade assembling of salicylaldehydes and dimethylbarbituric acid into 5-(1,3-dimethyl-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-triones | |
article | |
Michail N. Elinson1  Anatoly N. Vereshchagin1  Alexander D. Korshunov1  Mikhail P. Egorov1  | |
[1] N. D. Zelinsky Institute of Organic Chemistry | |
关键词: barbiturates; cascade reaction; catalysis; chromeno[2; 3-d]pyrimidines; cyclization; salicylaldehydes; | |
DOI : 10.1515/hc-2018-0015 | |
学科分类:内科医学 | |
来源: De Gruyter | |
【 摘 要 】
A fast (15 min) and efficient cascade reaction of salicylaldehydes and 1,3-dimethylbarbituric acid in the presence of p -TsOH as a catalyst furnishes substituted 5-(1,3-dimethyl-2,4-dioxo-1,3,4,5-tetrahydro-2 H -chromeno[2,3- d ]pyrimidin-5-yl)-1,3-dimethylpyrimidine-2,4,6(1 H ,3 H ,5 H )-triones 1a–h , containing both chromeno[2,3- d ]pyrimidine and hexahydropyrimidine-2,4,6-trione pharmacologically active fragments, in 95–99% yields. This new procedure is characterized by the use of inexpensive reagents and a simple workup.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
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RO202107200002277ZK.pdf | 130KB | download |