Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Polymers

Yiluo Hu¹  Daham Jeong¹  Yohan Kim¹  Seonmok Kim¹  Seunho Jung¹ 

[1] Department of Systems Biotechnology & Dept. of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 05029, Korea;

关键词: succinoglycan;    polysaccharide;    metal coordination hydrogel;    gel-sol conversion;    drug release;   

DOI  :  10.3390/polym12040977

来源: DOAJ

【 摘 要 】

Hydrogel materials with a gel-sol conversion due to external environmental changes have potential applications in a wide range of fields, including controlled drug delivery. Succinoglycans are anionic extracellular polysaccharides produced by various bacteria, including Sinorhizobium species, which have diverse applications. In this study, the rheological analysis confirmed that succinoglycan produced by Sinorhizobium meliloti Rm 1021 binds weakly to various metal ions, including Fe²⁺ cations, to maintain a sol form, and binds strongly to Fe³⁺ cations to maintain a gel form. The Fe³⁺-coordinated succinoglycan (Fe³⁺-SG) hydrogel was analyzed by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, circular dichroism (CD), and field-emission scanning electron microscopy (FE-SEM). Our results revealed that the Fe³⁺ cations that coordinated with succinoglycan were converted to Fe²⁺ by a reducing agent and visible light, promoting a gel-sol conversion. The Fe³⁺-SG hydrogel was then successfully used for controlled drug delivery based on gel-sol conversion in the presence of reducing agents and visible light. As succinoglycan is nontoxic, it is a potential material for controlled drug delivery.

【 授权许可】

Unknown