A flavonoid-rich extract of orange juice reduced oxidative stress in an experimental model of inflammatory bowel disease

Journal of Functional Foods

Michele Navarra¹  Roberta Fusco²  Santa Cirmi²  Salvatore Cuzzocrea²  Rosanna Di Paola²  Enrico Gugliandolo² 

[1] Department of Pharmacology and Physiology, Saint Louis University, 1402 South Grand Blvd, Saint Louis 63104, MO, USA;Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31, I-98166 Messina, Italy;

关键词: Citrus sinensis;    Colitis;    Oxidative stress;    Inflammation;    Orange juices;    Flavonoids;   

DOI  :  

来源: DOAJ

【 摘 要 】

Flavonoids may be effective in preventing chronic degenerative diseases linked to oxidative stress, which in turn is involved in the etiopathogenesis of inflammatory bowel disease.This study was designed to assess the effects of a flavonoid-rich extract of orange juice (OJe) in mice exposed to experimental colitis.Four days of intracolonic injection of dinitrobenzene sulfonic acid (DNBS) caused colitis in mice. Daily oral administration of OJe decreased the loss of body weight caused by DNBS, lowered neutrophil infiltration, nitrotyrosine and PAR stainings, both TNF-α and IL-1β generation, nuclear NF-κB translocation, levels of ICAM-1 and P-selectin as well as increased MPO activity, enhanced MnSOD expression and modulated that of Bcl-2 and Bax.Our results indicate that OJe may be used as functional food in case of colonic oxidative stress-induced inflammation, representing a new healthy approach to avoid ulcerative colitis.

【 授权许可】

Unknown