Mitochondrial Calcium Signaling in Pancreatic β-Cell

International Journal of Molecular Sciences

JeromeN. Feige¹  Anna Weiser¹  Umberto De Marchi¹ 

[1] Nestlé Research—EPFL Innovation Park, CH-1015 Lausanne, Switzerland;

关键词: mitochondria;    calcium;    insulin secretion;    β-cell;    diabetes;   

DOI  :  10.3390/ijms22052515

来源: DOAJ

【 摘 要 】

Accumulation of calcium in energized mitochondria of pancreatic β-cells is emerging as a crucial process for pancreatic β-cell function. β-cell mitochondria sense and shape calcium signals, linking the metabolism of glucose and other secretagogues to the generation of signals that promote insulin secretion during nutrient stimulation. Here, we describe the role of mitochondrial calcium signaling in pancreatic β-cell function. We report the latest pharmacological and genetic findings, including the first mitochondrial calcium-targeted intervention strategies developed to modulate pancreatic β-cell function and their potential relevance in the context of diabetes.

【 授权许可】

Unknown