Dual Role of Nitric Oxide in Pancreatic β-Cells

Journal of Pharmacological Sciences

Tomohisa Ishikawa¹  Yukiko Kurohane Kaneko¹ 

[1] Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Japan

关键词: nitric oxide;    pancreatic islet;    β-cell;    insulin secretion;    apoptosis;   

DOI  :  10.1254/jphs.13R10CP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(51)Cited-By(7)An involvement of inducible nitric oxide (NO) synthase (NOS) in pancreatic β-cell degeneration during the process of type 1 diabetes has been well discussed. Recently, there is growing evidence for pivotal roles of constitutive NOS (cNOS) in β-cells; the presence of NOS1 and NOS3 in pancreatic β-cells and the effects of low-concentration NO, which is assumed to be derived from cNOS, on β-cell functions have been reported. However, the roles of cNOS-derived NO in β-cells are still under debate. One of the reasons seems to be that NO has multiple biological activities, which are dependent on its concentration. In β-cells, NO has been shown to exert positive and negative regulation of insulin secretion and anti- and pro-apoptotic activities, which is likely to be dependent on concentrations. In this review article, we will describe the current understanding of the roles of NO in pancreatic β-cells, especially focusing on cNOS-derived NO and its differential roles depending on concentrations.

【 授权许可】

Unknown