Additive effect of aortic regurgitation degree on left ventricular strain in patients with type 2 diabetes mellitus evaluated via cardiac magnetic resonance tissue tracking

Cardiovascular Diabetology

Meng-Ting Shen¹  Zhi-Gang Yang¹  Li Jiang¹  Li-Ting Shen¹  Rui Shi¹  Yuan Li¹  Shan Huang¹  Ya-Wen Zhu² 

[1] Department of Radiology, West China Hospital, Sichuan University;Division of General Practice, West China Hospital, Sichuan University;

关键词: Type 2 diabetes mellitus;    Aortic regurgitation;    Left ventricle;    Strain;    Magnetic resonance imaging;   

DOI  :  10.1186/s12933-022-01471-2

来源: DOAJ

【 摘 要 】

Abstract Background Type 2 diabetes mellitus causes left ventricular (LV) remodeling and increases the risk of aortic regurgitation (AR), which causes further heart damage. This study aimed to investigate whether AR aggravates LV deformation dysfunction and to identify independent factors affecting the global peak strain (PS) of LV remodeling in patients with type 2 diabetes mellitus (T2DM) who presented with AR and those without T2DM. Methods In total, 215 patients with T2DM and 83 age- and sex-matched healthy controls who underwent cardiac magnetic resonance examination were included. Based on the echocardiogram findings, T2DM patients with AR were divided into three groups (mild AR [n = 28], moderate AR [n = 21], and severe AR [n = 17]). LV function and global strain parameters were compared, and multivariate analysis was performed to identify the independent indicators of LV PS. Results The T2DM patients with AR had a lower LV global PS, peak systolic strain rate (PSSR), and peak diastolic strain rate (PDSR) in three directions than those without AR and non-T2DM controls. Patients without AR had a lower PS (radial and longitudinal) and PDSR in three directions and higher PSSR (radial and longitudinal) than healthy controls. Further, regurgitation degree was an independent factor of LV global radial, circumferential, and longitudinal PS. Conclusion AR may aggravate LV stiffness in patients with T2DM, resulting in lower LV strain and function. Regurgitation degree and sex were independently correlated with LV global PS in patients with T2DM and AR.

【 授权许可】

Unknown