The Comparative Effect of Pomegranate Peel Extract and Dapagliflozin on Body Weight of Male Albino Wistar Rats with Type 2 Diabetes Mellitus

9th Annual Basic Science International Conference 2019

自然科学（总论）

Ramadhani, Devi Trisna^1 ; Rezkia Amradani, Rafi Amanda^2 ; Ulfia, Mila^2 ; Utami, Suryaningtyas Margi^2 ; Indarto, Dono^1^2^3 ; Wasita, Brian^1^4

Postgraduate Program of Nutrition Sciences, Universitas Sebelas Maret, Surakarta, Indonesia^1

Biomedical Laboratory, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia^2

Department of Physiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia^3

Department of Anatomy Pathology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia^4

关键词: Body weight;    Co-transporters;    Pomegranate Peel Extract;    Type 2 diabetes mellitus;    Wistar rat;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/546/6/062023/pdf
DOI  :  10.1088/1757-899X/546/6/062023

学科分类：自然科学（综合）

来源: IOP

【 摘 要 】

Sodium Glucose Co-Transporter 2 (SGLT2) inhibitor is the second line of type 2 diabetes mellitus (T2DM) treatment. From in silico and in vitro studies, ellagic acid in pomegranate fruits has a similar effect to the SGLT2 inhibitor. This study aimed to investigate the effect of pomegranate peel extract (PPE) on body weight (BW) of male rats with T2DM. Male Albino Wistar rats, which aged 8 weeks and weighed 150-200 g were induced with single dose of 230 mg/kgBW nicotinamide and 65 mg/kgBW streptozotocin intraperitoneally. The control group consisted of 14 rats with T2DM and randomly divided into the negative control (NC) and the positive control (PC) treated with 0.18 mg/kgBW/day dapaglifozin. Twenty one rats with T2DM were divided into 3 treatment groups (T1-3) and given with 50, 100, and 200 mg/kgBW/day PPE respectively for 14 days. Collected data were analyzed using ANOVA and LSD post hoc tests with p value