Probiotic assisted weight management as a main factor for glycemic control in patients with type 2 diabetes: a randomized controlled trial

Diabetology & Metabolic Syndrome

Research

Beitullah Alipour¹  Leila Khalili²  Tohid Hassanalilou²  Mohammad Asghari Jafarabadi³  Mehran Mesgari Abbasi⁴  Ismail Faraji⁵ 

[1] Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran;Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran;Department of Statistics and Epidemiology, Faculty of Health, Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran;Internist, Fellow of Endocrinology, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran;

关键词: Lactobacillus casei;    Type 2 diabetes mellitus;    Body weight;    Dietary intake;    Glycemic control;   

DOI  :  10.1186/s13098-019-0400-7

 received in 2018-01-26, accepted in 2019-01-04,  发布年份 2019

来源: Springer

【 摘 要 】

ObjectivesTo evaluate the effect of Lactobacillus casei 01 on dietary intake, body weight, and glycemic control in patients with T2DM.MethodForty patients with T2DM (n = 20 for each group) were assigned into two groups in present trial. The patients in the probiotic group received a daily capsule containing a minimum of 108 CFU of L. casei 01 for 8 week. The placebo group took capsules filled with maltodextrin for the same time period. Dietary intake questionnaires and anthropometric measurements were collected, and the participants were assessed by an endocrinologist at baseline and at the end of the trial.ResultsLactobacillus casei 01 supplementation significantly decreased total energy, carbohydrate, fat, and protein intake compared with placebo (p = 0.001, p = 0.002, p = 0.009, p = 0.001; respectively). Moreover weight, BMI, and waist circumference were significantly decreased in intervention group compared with placebo group (p < 0.001; p < 0.001; p = 0.029; respectively). In comparison with placebo group serum fetuin-A level, fasting blood sugar, insulin concentration, and insulin resistance were significantly decreased (p = 0.023, p =0.013, p = 0.028; p = 0.007; respectively), and serum SIRT1 level was significantly increased (p = 0.040) in intervention group.ConclusionsLactobacillus casei 01 supplementation affected dietary intake and body weight in a way that improved fetuin-A and SIRT1 levels and glycemic response in subjects with T2DM. Affecting the fetuin-A and SIRT1 levels introduces a new known mechanism of probiotic action in diabetes management.

【 授权许可】

CC BY   
© The Author(s) 2019

【 图 表 】

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