Small leucine-rich proteoglycans in physiological and biomechanical function of bone

Matrix Biology Plus

Jean X. Jiang¹  Rui Hua² 

[1] Corresponding author.;Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA;

关键词: Proteoglycans;    Glycosaminoglycans;    Bound water;    Bone toughness;    Aging;   

DOI  :  

来源: DOAJ

【 摘 要 】

Proteoglycans (PGs) contain long unbranched glycosaminoglycan (GAG) chains attached to core proteins. In the bone extracellular matrix, PGs represent a class of non-collagenous proteins, and have high affinity to minerals and collagen. Considering the highly negatively charged character of GAGs and their interfibrillar positioning interconnecting with collagen fibrils, PGs and GAGs play pivotal roles in maintaining hydrostatic and osmotic pressure in the matrix. In this review, we will discuss the role of PGs, especially the small leucine-rich proteoglycans, in regulating the bioactivity of multiple cytokines and growth factors, and the bone turnover process. In addition, we focus on the coupling effects of PGs and GAGs in the hydration status of bone extracellular matrix, thus modulating bone biomechanical properties under physiological and pathological conditions.

【 授权许可】

Unknown