Vagally Mediated Gut-Brain Relationships in Appetite Control-Insights from Porcine Studies

Nutrients

Charles-Henri Malbert¹ 

[1] Aniscan Unit, INRAE, Saint-Gilles, 35590 Paris, France;

关键词: miniature pig;    pig model;    functional brain imaging;    molecular imaging;    vagal afferents;    single fiber recording;   

DOI  :  10.3390/nu13020467

来源: DOAJ

【 摘 要 】

Signals arising from the upper part of the gut are essential for the regulation of food intake, particularly satiation. This information is supplied to the brain partly by vagal nervous afferents. The porcine model, because of its sizeable gyrencephalic brain, omnivorous regimen, and comparative anatomy of the proximal part of the gut to that of humans, has provided several important insights relating to the relevance of vagally mediated gut-brain relationships to the regulation of food intake. Furthermore, its large size combined with the capacity to become obese while overeating a western diet makes it a pivotal addition to existing murine models, especially for translational studies relating to obesity. How gastric, proximal intestinal, and portal information relating to meal arrival and transit are encoded by vagal afferents and their further processing by primary and secondary brain projections are reviewed. Their peripheral and central plasticities in the context of obesity are emphasized. We also present recent insights derived from chronic stimulation of the abdominal vagi with specific reference to the modulation of mesolimbic structures and their role in the restoration of insulin sensitivity in the obese miniature pig model.

【 授权许可】

Unknown